Weight Loss Medication Safety Information
Important safety information, MHRA warnings, and guidance for GLP-1 weight loss medications.
This Page Is Not Medical Advice
The information below is drawn from official MHRA publications, NICE guidance, and product information sheets (SmPCs). It is intended for general awareness only. Always read the patient information leaflet supplied with your medication, and consult your GP or pharmacist if you have any concerns.
Key Safety Warnings
Pancreatitis Risk
GLP-1 medications carry a small risk of acute pancreatitis. Seek immediate medical attention if you experience severe, persistent abdominal pain — especially if it radiates to your back.
Source: MHRA, January 2026 →Counterfeit Medicines
The MHRA has issued warnings about fake weight loss injections (including counterfeit Ozempic and Saxenda) being sold online without prescriptions. Only buy from GPhC-registered pharmacies.
Source: MHRA Alert →Pregnancy & Breastfeeding
GLP-1 medications should not be used during pregnancy or breastfeeding. If you become pregnant or plan to become pregnant, stop treatment and consult your GP immediately.
Source: EMC SmPC →Thyroid Cancer (Precautionary)
GLP-1 medications are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2).
Source: EMC SmPC →Gallbladder Issues
Rapid weight loss (from any cause) increases the risk of gallstones. Report any symptoms of gallbladder problems (upper abdominal pain, especially after eating fatty foods) to your prescriber.
Source: NICE CG189 →Mental Health
The EMA and MHRA are reviewing reports of suicidal thoughts linked to GLP-1 medications. If you experience changes in mood or thoughts of self-harm, contact your GP or call NHS 111 immediately.
Source: MHRA Review →
When to Seek Help
Contact your GP, pharmacist, or call NHS 111 if you experience:
- Severe or persistent abdominal pain
- Persistent vomiting or diarrhoea that does not improve
- Signs of an allergic reaction (rash, swelling, difficulty breathing)
- Changes in mood, anxiety, or thoughts of self-harm
- Symptoms of gallbladder problems (upper abdominal pain after eating)
In an emergency, call 999 or go to A&E.
Important Medical Information
This website provides general information about weight loss medications for educational purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult your GP or qualified healthcare professional before starting any weight loss medication. Individual results may vary.
WhichWeightMeds.org is an independent comparison platform and is not affiliated with any pharmacy, manufacturer, or healthcare provider. We do not prescribe, sell, or dispense medications.
Sources & References
- 1GLP-1 medicines for weight loss and diabetes — what you need to know — MHRA (Accessed February 2026)View source
- 2
- 3MHRA urges public to avoid illegal online weight loss medicines — MHRA (Accessed February 2026)View source
- 4Obesity: identification, assessment and management (CG189) — NICE (Accessed February 2026)View source