Common Side Effects (SCALE Trial)
The SCALE Obesity and Prediabetes trial reported the following common side effects with liraglutide 3.0mg daily.
Most common. Usually worst in the first 2 weeks of each dose level.
Typically mild and transient.
Increasing fibre and fluid intake helps.
More common during dose escalation.
Expected therapeutic effect.
Indigestion. Smaller meals recommended.
Usually mild. Severe pain needs assessment.
Due to daily injection frequency. Rotate sites.
Serious Side Effects
Acute pancreatitis
Severe persistent abdominal pain. Stop medication and seek immediate medical help.
Gallbladder disease
Higher rates of gallstones and cholecystitis observed. Watch for upper right abdominal pain and nausea.
Thyroid C-cell tumours
Observed in animal studies. Contraindicated in patients with personal/family history of MTC or MEN2.
Hypoglycaemia
Risk is increased if taking other diabetes medications. Monitor blood sugar if applicable.
Increased heart rate
Sustained resting heart rate increase reported. Monitor if you have cardiac conditions.
Daily Injection Consideration
Because Saxenda is injected daily (unlike weekly Mounjaro and Wegovy), injection site reactions are more common. Rotate between abdomen, thigh, and upper arm to minimise discomfort.